BOC-L-Phenylglycine（CAS# 2900-27-8)
| Whakaahuatanga Haumaru | S22 – Kaua e pupuhi puehu. S24/25 – A ape i te pa ki te kiri me nga kanohi. |
| WGK Tiamana | 3 |
| Waehere HS | 2924 29 70 |
Kupu Whakataki
Ko te N-Boc-L-Phenylglycine he pūhui waro i hangaia e te hanganga o te hononga matū i waenga i te roopu amino (NH2) o te glycine me te roopu carboxyl (COOH) o te waikawa benzoic. Kei roto i tona hanganga he roopu whakamarumaru (Boc group), he roopu tert-butoxycarbonyl, e whakamahia ana hei tiaki i te tauhohenga o te roopu amino.
Kei a N-Boc-L-phenylglycine nga ahuatanga e whai ake nei:
- Te ahua: Ma te kirikiriata ma
- Wairewa: Ka whakarewahia ki etahi whakarewa pararopi, penei i te dimethylformamide (DMF), te dichloromethane, etc
Ko te N-Boc-L-phenylglycine e whakamahia nuitia ana i roto i nga tauhohenga maha-taahiraa i roto i te whakahiato waro, ina koa mo te whakahiato o nga pūhui peptide. Ko te roopu whakamarumaru Boc ka taea te whakakorehia e nga tikanga waikawa, kia taea ai te hohenga o te roopu amino katahi ka mahi i nga tauhohenga o muri mai. Ka taea hoki te whakamahi i te N-Boc-L-phenylglycine hei pärönaki mo te hanga o nga pokapū chiral i roto i te peptide synthesis.
Ko te whakaritenga o te N-Boc-L-phenylglycine te nuinga o nga mahi e whai ake nei:
Ko te Glycine he mea whakamaarama ki te waikawa benzoic kia whiwhi i te waikawa benzoic-glycinate ester.
Ma te whakamahi i te tauhohenga lithium borotrimethyl ether (LiTMP), i protonated te ester benzoic acid-glycinate me te tauhohe ki te Boc-Cl (tert-butoxycarbonyl chloride) kia whiwhi ai i te N-Boc-L-phenylglycine.
- Ko te N-Boc-L-phenylglycine pea ka whakapataritari i nga kanohi, kiri, me te waahanga manawa, a me karo i te wa e whakamahia ana.
- Ko nga taputapu whakamarumaru whaiaro penei i nga karapu taiwhanga, karaehe haumaru, me etahi atu me mau i te wa e mahi ana.
- Me mahi i roto i te taiao taiwhanga hau pai.
- A ape i te pa atu ki nga waiora me nga waikawa kaha i te wa e rongoa ana.
- Mena ka horomia, ka ngotea ranei, me rapu wawe i te rongoa, mauria mai he ipu o te puhui, me te tuku korero haumaru e tika ana ki te taote.
