Dodec-11-yn-1-ol（CAS# 18202-10-3)

Āhuatanga matū:

Tātai rāpoi	C12H22O
Molar Mass	182.3
Kiato	0.8530 (whakatau tata)
Te Whakarewa	18.8°C (whakatau tata)
Piro Pouri	285.73°C (whakatau tata)
pKa	15.20±0.10(Te Matapae)
Tikanga Rokiroki	2-8°C
Taurangi Refactive	1.4535 (whakatau tata)

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Dodec-11-yn-1-ol（CAS# 18202-10-3) Nga korero

whakarite

NaH(7.5g,60% te marara hinu, 326mmol) i tapirihia he puranga ma te puranga ki te dodecyl -3-alkyne -1-waipiro (10.0g,54.95mmol;GF Smith) i roto i te wairewa 0 ℃ o te ethylenediamine (40mL). I muri i te 1 haora, ka piki te pāmahana ki te 70 ℃. I muri i te 8 haora, whakamataohia te ranunga tauhohenga ki te 0°C, ka ata whakamutua ki te wai tio-matao (100mL), ka tango ki te ether (3 × 60mL). I horoia te tangohanga ether ki te wai (100mL). Ko te horoinga wai i tangohia ki muri me te ether (3 × 60mL). Ko nga tangohanga pararopi kua whakakotahihia i raro i te korehau, a ko nga toenga ka tukuna ki te chromatography tīwae ma te whakamahi i te 10% EtOAc/hexane kia whiwhi ai i te 11-dodecyne -1-waipiro (7.4g,74%) kua pokea ki te 3-5% o etahi atu imaera rohe ( regioisomer). TLC:30% EtOAc/hexane, Rf ≈ 0.4;1H NMR(300MHz,CDCl3)δ3.66(t,2H,J = 7.3Hz), 2.14-2.21(m,2H),1.93(t,J = 1.9Hz ,1H),1.20-1.63(m,16H).

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