Fmoc-L-glutamic acid-gamma-benzyl ester (CAS # 123639-61-2)
Ko te Fluorene methoxycarbonyl-L-glutamic acid-Γ-benzyl he pūhui waro e whakamahia ana i roto i te whakahiato peptide i roto i te whakahiato-waahanga totoka. Ko tona ahua:
- Te ahua: He ma ki te kowhai kowhai totoka
- Wairewa: Fmoc-L-Glu(OtBu)-OH he pai te whakarewatanga i waenga i nga whakarewa waro noa.
Ko te whakamahinga matua o Fmoc-L-Glu (OtBu)-OH he roopu tiaki i roto i te whakahiato peptide. I te wa e whakahiato ana i nga mekameka peptide, ka herea a Fmoc-L-Glu(OtBu)-OH ki nga waikawa amino, ma te tiaki i a raatau mahi ki nga tauhohenga kore-motuhake me etahi atu tauhohenga. I muri i te otinga o te tauhohenga, ka taea te tango i te Fmoc-L-Glu(OtBu)-OH ma te tango i te roopu whakamarumaru hei whakaora i te mahi o nga waikawa amino.
Ko te whakaritenga o Fmoc-L-Glu(OtBu)-OH he tino uaua me te tikanga me whakamahi he raupapa o nga hikoi whakahiato waro. Ka tauhohehia te waikawa Glutamic ki te bromoacetate kia whiwhi ai i te ethyl glutamate. Na, ka tauhohehia te ethyl glutamate ki te waipiro benzyl ki te hanga ethyl glutamate benzyl alcohol ester. Ko te Ethyl glutamate benzyl alcohol ester i tauhohe ki te Fmoc-Cl ki te whakaputa i te hua Fmoc-L-Glu(OtBu)-OH.
Mōhiohio Haumaru: Fmoc-L-Glu(OtBu)-OH he rongoa taiwhanga me whakamahia i raro i nga mahi taiwhanga haumaru. Me whai i nga tikanga haumaru taiwhanga whanui, tae atu ki te mau taputapu whakamarumaru whaiaro (hei tauira, nga karapu taiwhanga, mowhiti, me etahi atu), te karo i te pa ki te kiri me te ngongo, me te mahi i roto i te taiwhanga hau pai. Me penapena te pūhui ki roto i te ipu hau, kia matara atu i te mura me te hāora.
