L-Pyroglutamic acid CAS 98-79-3
Morearea me te Haumaru
| Nga Tohu Whakamate | Xi – Irritant |
| Waehere Morearea | 36/37/38 – He whakapataritari ki nga kanohi, te punaha manawa me te kiri. |
| Whakaahuatanga Haumaru | S26 – Mena ka pa ki nga kanohi, horoi tonu ki te nui o te wai me te rapu tohutohu hauora. S36 – Mau kakahu whakamarumaru tika. S37/39 – Kia mau nga karapu tika me te whakamarumaru kanohi/kanohi |
| WGK Tiamana | 3 |
| RTECS | TW3710000 |
| FLUKA BRAND F CODES | 21 |
| TSCA | Ae |
| Waehere HS | 29337900 |
| Kupu Whakataki | Ko te waikawa pyroglutamic he 5-oxyproline. He mea hanga na te matewai i waenga i te roopu α-NH2 me te roopu γ-hydroxyl o te waikawa glutamic hei hanga i te herenga lactam ngota; Ka taea hoki te hanga ma te ngaro o te roopu Amido i roto i te ngota ngota glutamine. Mena he ngoikore te glutathione synthetase, ka puta pea te pyroglutamemia, he raupapa tohu tohu haumanu. Ko te Pyroglutamemia he mate o te paopaotanga waikawa waro na te ngoikoretanga o te glutathione synthetase. Nga whakaaturanga haumanu o te whanautanga 12 ~ 24 haora o te tiimata, te hemolysis ahu whakamua, te jaundice, te Acidosis Metabolic roa, nga mate hinengaro, me etahi atu; Kei roto i te mimi he waikawa pyroglutamic, waikawa lactic, Alpha deoxy4 glycoloacetic acid lipid. Maimoatanga, tohumate, whakarongo ki te whakatika i te kai i muri i te tau. |
| taonga | Ko te waikawa L-pyroglutamic, e mohiotia ana ko te waikawa L-pyroglutamic, te waikawa L-pyroglutamic. Mai i te ewaro me te hinu etera ranunga i roto i te rerenga o te orthorhombic koeko rua Crystal, ira whakarewa o 162~163 ℃. Ka whakarewahia ki te wai, te waipiro, te acetone me te waikawa acetate, te ethyl acetate-soluble, kare e rewa i te etera. Te hurihanga whatu motuhake -11.9 °(c = 2,H2O). |
| Nga ahuatanga me nga whakamahinga | kei roto i te kiri o te tangata he mahi whakamakuku o nga matū wairewa-wairewa-taiao moisturizing, tona hanganga he waikawa amino (kei roto 40%), waikawa pyroglutamic (kei roto 12%), tote parakore (Na, K, Ca, Mg, etc. kei roto 18.5%), me etahi atu puhui waro (kei roto 29.5%). Na reira, ko te waikawa pyroglutamic tetahi o nga waahanga matua o te take whakamakuku maori o te kiri, a, ko te kaha o te makuku he nui atu i te glycerol me te propylene glycol. A kore-paitini, kahore he whakaongaonga, ko te Tiaki Kiri hou, Tiaki makawe whakapaipai rawa rawa rawa. Ko te waikawa Pyroglutamic ano he aukati i te mahi o te tyrosine oxidase, na reira ka aukati i te tukunga o nga matū "melanoid" i roto i te kiri, he maamaa te kiri. He whakangawari ki te kiri, ka taea te whakamahi mo nga whakapaipai whao. I tua atu i te tono i roto i nga mea whakapaipai, ka taea ano e te waikawa L-pyroglutamic te whakaputa i nga pärönaki me etahi atu puhui pararopi, he paanga motuhake ki runga i nga mahi o te mata, he maamaa me te kanapa, me etahi atu. Reagents matū mo te whakatau i nga amine racemic; takawaenga organic. |
| tikanga whakarite | Ko te waikawa L-pyroglutamic ka hangaia ma te tango i te meneti kotahi o te wai mai i te ngota o te waikawa L-glutamic, a he ngawari tana mahi whakarite, ko nga mahi matua ko te whakahaere i te pāmahana me te wa whakamakuku. (1) Ko te 500 karamu o te waikawa L-glutamic i whakauruhia ki roto i te ipurau 100 ml, ka whakamahanahia te ipurau ki te pati hinu, ka piki ake te mahana ki te 145 ki te 150 ° C., ka mau tonu te mahana mo te 45 meneti mo te maroketanga. tauhohenga. Ko te wairewa maroke ko Tan. (2) i muri i te otinga o te tauhohenga matewai, ka ringihia te wairewa ki roto i te wai kohua me te 350 pea te rahi, ka rewa katoa te otinga ki te wai. Whai muri i te whakamatao ki te 40 ki te 50 ° C., ka taapirihia he waro whakakorikori e tika ana mo te whakapoipoi (e rua nga wa). I whiwhihia he otinga marama kore tae. (3) i te wa e whakamahana tika ana te otinga marama kore tae i te taahiraa (2) ka whakaeto ki te whakaiti i te rōrahi ki te haurua, huri ki te pati wai ka aro tonu ki te 1/3, ka taea e koe te aukati i te whakamahana, a i roto i te kaukau wai wera ki te puhoi te whakatioatanga, 10 ki te 20 haora i muri i te whakaritenga o nga tioata prismatic taekore. Ko te nui o te waikawa L-pyroglutamic i roto i nga mea whakapaipai ka whakawhirinaki ki te hanganga. Ka taea hoki te whakamahi i tenei hua i runga i nga whakapaipai i te ahua o te otinga 50%. |
| waikawa glutamic | Ko te waikawa glutamic he waikawa amino e hanga ana i te pūmua, he mekameka taha waikawa katote, me te whakaatu hydrotropism. Ko te waikawa glutamic e whakaraerae ana ki te huringa ki roto ki te pyrrolidone carboxylic acid, I.e., pyroglutamic acid. He tino nui te waikawa glutamic i roto i nga pūmua pata katoa, e whakarato ana i te alpha-ketoglutarate i roto i te huringa waikawa tricarboxylic. Ko te waikawa alpha ketoglutaric ka taea te whakahiato tika mai i te haukini i raro i te catalysis o te glutamate dehydrogenase me te NADPH (coenzyme II), ka taea hoki te whakakorikori e te aspartate aminotransferase ranei alanine aminotransferase, ka puta te waikawa glutamic e te whakawhitinga o te waikawa aspartic ranei alanine; I tua atu, ka taea te huri i te waikawa glutamic ki te proline me te ornithine (mai i te arginine), ia. No reira ko te Glutamate he waikawa amino kore-take. Ka whakakorehia te waikawa glutamic i raro i te catalysis o te glutamate dehydrogenase me te NAD (coenzyme I) ka nekehia ranei i waho o te roopu amino i raro i te catalysis o te aspartate aminotransferase me te alanine aminotransferase hei whakaputa i te alpha ketoglutarate, ka uru ki te huringa waikawa tricarboxylic me te whakaputa huka ma te ara gluconeogenic, no reira he waikawa amino glycogenic nui te waikawa glutamic. Ko te waikawa glutamic i roto i nga kopa rereke (penei i te uaua, te ate, te roro, me etahi atu) ka taea te whakahiato i te glutamine me te NH3 na roto i te catalysis o te glutamine synthetase, ko te hua detoxification o te haukini, ina koa i roto i te kiko roro, me te momo rokiroki me te whakamahi te haukini i roto i te tinana (tirohia te "glutamine me tona metabolism"). Ko te waikawa glutamic ka whakahiatohia me te acetyl-CoA hei cofactor o te mitochondrial carbamoyl phosphate synthase (e uru ana ki te whakahiato o te Urea) na roto i te catalysis o te acetyl-glutamate synthase. Ko te waikawa γ-aminobutyric (GABA) he hua o te decarboxylation o te waikawa glutamic, ina koa i roto i nga kohinga teitei i roto i te kiko roro, ka puta ano hoki i roto i te toto, ko tana mahi a-tinana e kiia ana ko te neurotransmitter aukati, nga hua antispasmodic me te hypnotic i mahia e te ka taea te whaowhia haumanu o te echinocandin ma te GABA. Ko te catabolism o GABA ka uru ki te huringa waikawa tricarboxylic ma te huri i te GABA transaminase me te aldehyde dehydrogenase ki te waikawa succinic hei hanga i te GABA shunt. |
| Whakamahi | whakamahia hei takawaenga i roto i te whakahiato waro, taapiri kai, aha atu. whakamahia i roto i te kai, rongoa, poke me etahi atu ahumahi |
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