Methoxymethyl triphenylphosphonium chloride（CAS# 4009-98-7)

Whakamahinga

(Methoxymethyl) triphenylphosphorus chloride e whakamahia ana ki te whakahiato i te cefaltacin, he rongoa patu huaketo me te mate pukupuku. Ka whakamahia ano ki te whakahiato i tetahi kongakonga o te paclitaxel.

Whakaritenga

He tikanga mo te whakahiato (methoxymethyl) triphenylphosphorus chloride, e whai ake nei: i raro i te whakamarumaru o te hauota, te taapiri i te 50mL o te acetone anhydrous ki roto i te reactor, katahi ka taapirihia te 32g o te triphenylphosphine, te whakaoho me te whakanui i te pāmahana ki te 37°C, kia mau tonu te pāmahana. , ka tapirihia te 20g o te methyl chloromethyl ether ki te reactor, katahi te tauhohenga i te 37°C mo te 3h, ka piki haere te mahana ki te 47°C i te tere o te 1°C/min, ka haere tonu te tauhohenga mo te 3h, ka mutu te tauhohenga, ka 37.0g (methoxymethyl) triphenylphosphorus chloride i whiwhi ma te tātari. , anhydric ether te horoi me te whakamaroke me te hua o te 88.5%.