Methyl 2-cyanoisonicotinate（CAS# 94413-64-6)
Morearea me te Haumaru
| Te akomanga morearea | 6.1 |
Tikanga whakaputa
i whakaritea te pūhui i whäia e te waikura, te whakawhäiti me te whakamakuku me te methyl 2-methyl 4-pyridinecarboxylate (2) hei rauemi tïmata. i whakapumautia tona hanganga e 1H NMR me MS, a ko te katoa o nga hua ko 53.0%. Ko nga paanga o te tauwehenga kai, te pāmahana whakatioatanga, te wa tauhohenga me etahi atu mea i runga i te hua i akohia e nga whakamatautau tauwehe-kotahi, a ko nga tikanga o te tukanga i arotauhia: n(2):n (potassium permanganate) = 1.0:2.5, te pāmahana whakamaarama 0 ~5 ℃;n (methyl 2-carboxyl -4-pyridinecarboxylate):n (sulfoxide) = 1.0:1.4, tauhohenga; ka tohua e te tauhohenga matewai te punaha trifluoroacetic anhydride-triethylamine hei kaihoko whakamaroke. He ngawari te mahi, he ngawari nga tikanga tauhohenga, he ngawari ki te whakarahi i te whakaputanga, he pai te uara tono.
Whakamahi
Ka whakamahia te Tobisostat ki te rongoa i te hyperuricemia mau tonu o te kauti. Ka whakatauritea ki te allopurinol rongoa tuku iho (purine analog), kaore e pa ki te purine me te pyridine metabolism me te mahi enzyme, me te whakaiti i te waikawa uric Ka kaha ake te paanga, kaore e hiahiatia te whakahaere i te horopeta nui, ka pai ake te haumaru. Ko te Methyl 2-cyano-4-pyridine carboxylate he rauemi mata nui mo te whakahiato o Tobiso.
