Nicorandil（CAS# 65141-46-0)

Āhuatanga matū:

Tātai rāpoi	C8H9N3O4
Molar Mass	211.17
Kiato	1.4271 (whakatau tata)
Te Whakarewa	92°C
Piro Pouri	350.85°C (whakatau tata)
Tohu Kohiko	230°C
Wairewa	DMSO: >10 mg/mL. Wairewa i roto i te mewaro, te waiwaro, te acetone, te waikawa acetic glacial ranei, he paku whakarewa ki te chloroform, ki te wai ranei, tata kore e rewa i roto i te etera, i te benzene ranei.
Kohu Kohu	1.58E-08mmHg i te 25°C
Te ahua	Ma ki te ma-rite te paura tioata
Tae	ma ki te ma-ma
Merck	14,6521
Tikanga Rokiroki	2-8°C
Taurangi Refactive	1.7400 (whakatau tata)
MDL	MFCD00186520
Āhuatanga ā-tinana, matū hoki	Te paura tioata ma, he hongi, he paku noa ranei, he kawa. Ka whakarewahia ki te mewaro, te waiwaro, te acetone, te waikawa ahetiki ranei, he paku whakarewa ki te chloroform, ki te wai ranei, he ruarua nei kaore e memeha ki te etera, ki te benzene ranei. Ira whakarewa 88.5-93.5 °c. Paitini whakapeka LD50 kiore (mg/kg):1200-1300 waha, 800-1000 whakaroto.
Whakamahi	Mo te aukati i te mate ngakau coronary, angina pectoris
Te ako in vitro	Ko te Nicorandil (100 mM) te whakanui ake i te waikura flavoprotein, engari kaore i pa ki te awa o te membrane, te whakaora i nga awa mitoK(ATP) me te surfaceK(ATP) i nga kuhanga teitei ake i te 10-fold. Ka whakaitihia e Nicorandil te mate o te pūtau i roto i te tauira whakahiatotanga ischemic, he huanga cardioprotective e aukatihia ana e te mitoK(ATP) hongere aukati 5-hydroxydecanoic acid engari kaua e te surfaceK(ATP). Te awenga o te arai hongere HMR1098. Ko Nicorandil (100 mM) te whakakore i te ngaro o te TUNEL positivity, te whakawhitinga cytochrome C, te whakahohe caspase-3, me te kaha o te membrane mitochondrial (Delta (Psi) (m)). Ko te tātaritanga o nga pūtau kua pokea ki te tohu tohu Delta(Psi)(m)-tohu, tetramethylrhodamine ethyl ester (TMRE) na roto i te whakakorikori pūtau whakakorikori i whakaatu mai, ko te nicorandil te aukati i te whakahekenga o Delta(Psi)(m) i runga i te tikanga kukū (EC(50). ) āhua 40 mM, waiwai 100 mM). I roto i nga ruma e rua kua whakawhitia, i whakahohehia e Nicorandil tetahi hongere 80 pS K e whakatika ngoikore ana a roto, glibenclamide-tairongo. I roto i nga pūtau HEK293T, ko Nicorandil te pai ki te whakahohe i te hongere K(ATP) kei roto SUR2B. Ko Nicorandil (100 mM) i tino whakakorehia te maha o nga pūtau i roto i te karihi TUNEL-pai me te whakanui ake i te 20 mM h2o2-induced caspase-3 mahi. Ko te kukū a Nicorandil-e aukati ana i te ngaro o te DeltaPsim na te H2O2.
In vivo ako	Ko Nicorandil (2.5 mg/kg ia ra, po) me te Amlodipine (5.0 mg/kg ia ra, po) e toru nga ra o te mahi i tino aukati i nga huringa me te whakahoki i te mahi enzyme ki nga taumata tata ki nga kiore noa.

Tukuna he imeera ki a matou

Taipitopito Hua

Tohu Hua

Nga Tohu Whakamate	Xn – He kino
Waehere Morearea	R22 – He kino ki te horomia R41 – He kino kino ki nga kanohi
Whakaahuatanga Haumaru	S26 – Mena ka pa ki nga kanohi, horoi tonu ki te nui o te wai me te rapu tohutohu hauora. S39 – Mau whakamarumaru kanohi / kanohi.
WGK Tiamana	3
RTECS	US4667600
Waehere HS	29333990
Te paitini	LD50 i roto i te kiore (mg/kg): 1200-1300 ā-waha; 800-1000 iv (Nagano)

Kupu Whakataki

Ko Nicolandil, e mohiotia ana ko te nicorandil amine, he puhui waro. E whai ake nei he kupu whakataki mo nga rawa, te whakamahinga, te whakarite me nga korero haumaru o nicorandil:

Kounga:

- Ko te Nicorandil he toka kiriata kore tae e memeha ana i roto i te wai me te whakarewa pararopi.

- He pūhui kawakore ka tauhohe ki te waikawa ki te whakaputa pūhui tote.

- He pumau a Nicorandil i te hau, engari ka pirau ka pa ana ki te wera nui.

Whakamahia:

- Ka taea hoki te whakamahi i te Nicolandil i roto i te whakahiato o nga whakakoi whakakoi pararopi, photosensitizers, etc.

Tikanga:

- I te nuinga o te wa ka whakaritea a Nicolandil e te tauhohenga o te dimethylamine me te 2-carbonyl pūhui.

- Ka mahia te tauhohenga i raro i nga tikanga kawakore, ka mahia te tauhohenga whakawera i roto i te whakarewa tika.

Mōhiohio Haumaru:

- He haumaru te Nicorandil mo te tangata i raro i nga tikanga whanui.

- Heoi, kia tupato kia kore e pa ki nga kanohi, kiri, me te punaha manawa.