tert-butyl 2 4-dioxopiperidine-1-carboxylate（CAS# 845267-78-9)

Tātai rāpoi	C10H15NO4
Molar Mass	213.23
Kiato	1.199
Piro Pouri	373.8±35.0 °C(I Matapaetia)
Tohu Kohiko	179.9°C
Kohu Kohu	8.72E-06mmHg i te 25°C
pKa	10.67±0.20(I Matapaetia)
Tikanga Rokiroki	Puritia ki te wahi pouri, Hiri ki te maroke, Te Pawera Rua
Taurangi Refactive	1.493
MDL	MCD10566071

Taipitopito Hua

Waehere Morearea	20/21/22 – He kino ma te horomia, ka pa ki te kiri me te horomia.
Whakaahuatanga Haumaru	S23 – Kaua e hau kohu. S24/25 – A ape i te pa ki te kiri me nga kanohi.
WGK Tiamana	3
Waehere HS	29337900

Whakamahi	Ko te 2, 4-dipiperidon-1-formate tert-butyl formate ko te whakahiatotanga o te phenoxymethyl-dihydrothiazolopyridone derivatives Reactants i roto i te hua, hei tauira whakahuri i te hanganga pai (PAM) o te kaikawe glutamate 5(mGlu5).
tono	2, 4-dioperidone-1-tert-butyl formate te nuinga whakamahia rite organic takawaenga me te ho'oraa takawaenga, a taea te whakamahi i roto i te rangahau taiwhanga me te tukanga whanaketanga me te tukanga kōtuitanga rongoa matū.
whakarite	taahiraa a: tāpiri EDCI(191.7g) ki DMF(400mL) otinga o 3-(tert-butoxycarbonylamino) waikawa propionic (189.2g,1.0mol), waikawa meldamic (144.1g,1.0mol) me DMAP(135.0g,1.1mol ) whakamataohia e te pati huka, 1.0mol). Ko nga tauhohenga ka puta ka oho mo te po i te pāmahana rūma. I tineia te tauhohenga ki te 200mL H2O. Ko te ranunga hua ka taapirihia ki te H2O(2.0L) i raro i te whakaoho miihini. Ko te totoka i whiwhia ka tātarihia, ka tino horoia ki te wai ki te pH 7 kia whiwhi ai te hua (283g,90% hua). Hipanga B: He otinga o te 3-(2, 2-dimethyl-4, 6-dioxo-1, 3-dioxan-5-yl) -3-oxopropylcarbamate tert-butyl ester (100g,317.46mmol) i roto i te toluene (1500mL) ka whakamahana ki te 100°C mo te 4 haora. Ka whakamataohia nga tauhohenga ki te pāmahana rūma, ka kukū i raro i te pehanga iti kia whiwhi hua kore. Ko te hua (56g,83% hua) i purea e te MTBE- huri.